On the Intermediate State in Helix-Coil Transition
نویسندگان
چکیده
منابع مشابه
Solute effects on the helix-coil transition.
We discuss the effects of the solvent composition on the helix-coil transition of a polypeptide chain. We use a simple model to demonstrate that improving the hydrogen-bonding ability of the solvent can make the transition less cooperative, without affecting the transition temperature. This effect is very different from other solvent effects which primarily influence the melting transition rath...
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– The helix-coil transition is modified by grafting to a surface. This modification is studied for short peptides capable of forming α-helices. Three factors are involved: (i) the grafting can induced change of the boundary free energy of the helical domain (ii) the van der Waals attraction between the helices and (iii) the crowding induced stretching of the coils. As a result the helix-coil tr...
متن کاملKinetics of the helix-coil transition
Based on the Zimm-Bragg model we study cooperative helix-coil transition driven by a finite-speed change of temperature. There is an asymmetry between the coil→helix and helix→coil transition: the latter is displayed already for finite speeds, and takes shorter time than the former. This hysteresis effect has been observed experimentally, and it is explained here via quantifying system’s stabil...
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A simplified model for the closed circular DNA (ccDNA) is proposed to describe some specific features of the helix-coil transition in such molecule. The Hamiltonian of ccDNA is related to the one introduced earlier for the linear DNA. The basic assumption is that the reduced energy of the hydrogen bond is not constant through the transition process but depends effectively on the fraction of alr...
متن کاملTransition state and ground state properties of the helix-coil transition in peptides deduced from high-pressure studies.
Volume changes associated with protein folding reactions contain valuable information about the folding mechanism and the nature of the transition state. However, meaningful interpretation of such data requires that overall volume changes be deconvoluted into individual contributions from different structural components. Here we focus on one type of structural element, the α-helix, and measure ...
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ژورنال
عنوان ژورنال: Nippon kagaku zassi
سال: 1958
ISSN: 0369-5387,2185-0917
DOI: 10.1246/nikkashi1948.79.399